Researcher Discovers Endocrine-Resistant Breast Cancer, Opening The Possibility of New Therapeutic Strategies
The researchers from Harvard Medical School and Baylor College of Medicine have unveiled a novel mechanism that helps explain how endocrine-resistant breast cancer acquires metastatic behavior, opening the possibility of new therapeutic methods.
A study published within the Proceedings of the National Academy of Sciences, the research reveals that hyperactive FOXA1 signaling, which previously was reported in endocrine-resistant metastatic breast cancer, triggers genome-wide reprogramming that leads to enhanced resistance to treatment and metastatic behaviors.
The researchers additionally recognized HIF-2a as a key mediator of FOXA1-directed reprogramming and confirmed that an inhibitor of HIF-2a, presently underneath clinical development for therapy of superior renal cell carcinoma and recurrent glioblastoma, can successfully reduce migration and invasion of endocrine-resistant breast cancer cells expressing high FOXA1 activity.
However, most patients with metastatic disease, including those whose tumors responded initially to hormone therapy, ultimately relapse and die as a result of tumors’ acquired resistance to hormone therapy.
In earlier work, Schiff and her colleagues discovered that tumor cells immune to hormone therapies make more FOXA1 than susceptible cells, and this abundance of FOXA1 performs an energetic position in conferring resistance to the remedy. Within the present research, the researchers took a genome-wide approach to dig deeper into how FOXA1 accomplishes the complex activity of triggering metastatic behavior.
The researchers additionally found that FOXA1 doesn’t act alone. Together with different elements, it activates a lot of enhancers that work together to synchronize genome-wide cell reprogramming. HIF-2a is the top enhancer working with FOXA1 mediating the activation of pro-metastatic gene sets and pathways associated with the poor clinical end result.